abstract：:Diabetic nephropathy (DN) is known as a major microvascular complication leading cause of end-stage renal disease, it generally followed by the process of podocyte fragmentation and detachment. Transforming growth factor β1 (TGF-β1) signaling pathway plays a pivotal role in the initiation and progression of DN. In pre...

journal_title：American journal of translational research

authors： Xie S,Ge F,Yao Y,Zhang W,Wang S,Zhang M,Zhong R,Fang L,Qu D

更新日期：2019-09-15 00:00:00

abstract：:Formula-3 is a Chinese herbal medicine formula that was shown to inhibit food allergy in rats by stabilizing mast cells. But whether Formula-3 ameliorates food allergy through modulating the composition of intestinal microbiota remains to be explored. Here, we aimed to determine whether gut microbiota mediate the anti...

journal_title：American journal of translational research

authors： Liu S,Yang B,Yang P,Liu Z

更新日期：2019-09-15 00:00:00

abstract：:Accumulating evidence suggests that brain metabolic changes may be associated with the pathophysiology of schizophrenia. Both in vivo and in vitro studies have found glutamatergic and GABAergic abnormalities in different brain regions of individuals with schizophrenia. We report a longitudinal behavioral study in a me...

journal_title：American journal of translational research

authors： Yang J,Guo H,Sun D,Duan J,Rao X,Xu F,Manyande A,Tang Y,Wang J,Wang F

更新日期：2019-09-15 00:00:00

abstract：:The study was designed to investigate the effect of Nimesulide (NIM) on acute lung injury (ALI) in mice with severe acute pancreatitis (SAP). In our study, caerulein and LPS were employed to establish the ALI mice model induced by SAP. All animals were divided into four groups randomly: control, model (SAP), NIM low a...

journal_title：American journal of translational research

authors： Yang Z,Ji W,Li M,Qi Z,Huang R,Qu J,Wang H,Wang H

更新日期：2019-09-15 00:00:00

abstract：:Colorectal cancer, a common gastrointestinal malignant tumor, has been a leading cause of cancer related deaths. Long non-coding RNAs (lncRNAs) play an important role in regulating cancer development. The aim of this study was to investigate the role and potential mechanism of lncRNA AK001058 in colorectal cancer. To ...

journal_title：American journal of translational research

authors： Zheng S,Lin F,Zhang M,Mu N,Ge X,Fu J

更新日期：2019-09-15 00:00:00

abstract：:We tested the hypothesis that human induced pluripotent stem cell-derived mesenchymal stem cell (iPSC-MSC) therapy could effectively reduce brain-infarct volume (BIV) and improve neurological function in rat after acute intracranial hemorrhage (ICH) induced by a weight-drop device. Adult-male SD rats (n=40) were equal...

journal_title：American journal of translational research

authors： Chen KH,Lin KC,Wallace CG,Li YC,Shao PL,Chiang JY,Sung PH,Yip HK

更新日期：2019-09-15 00:00:00

abstract：:Understanding the relationships between glomerular endothelial cells (GECs) and glomerular mesangial cells (GMCs) is important to identify the molecular mechanisms underlying diabetic nephropathy (DN). Exosomes carried with mRNA, microRNA, and protein play important roles in cell-to-cell communication. In this study, ...

journal_title：American journal of translational research

authors： Ling L,Tan Z,Zhang C,Gui S,Cui Y,Hu Y,Chen L

更新日期：2019-08-15 00:00:00

abstract：:Osteoarthritis (OA) is a major global health problem; however, the etiology of the disease remains unknown and a reliable treatment strategy has yet to be discovered. Modulation of the receptor for glucagon-like peptide 1 (GLP-1) has emerged as a potential treatment strategy for various diseases including OA. In the p...

journal_title：American journal of translational research

authors： Mei J,Sun J,Wu J,Zheng X

更新日期：2019-08-15 00:00:00

abstract：:Circular RNAs (circRNAs) belong to non-coding RNAs and are known as key regulators in gene regulation. CircRNAs involve in the various biological processes of cancer. However, the functions of circRNAs in renal cell carcinoma (RCC) are still not clear. In this study, the circRNA expression profile was performed in the...

journal_title：American journal of translational research

authors： Jin C,Shi L,Li Z,Liu W,Zhao B,Qiu Y,Zhao Y,Li K,Li Y,Zhu Q

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:There is conflicting evidence regarding the prognostic value of cytotoxic T cell infiltration in breast cancer. The aims of this study were to detect the expression levels and localization of FoxP3 and CD8 in invasive ductal carcinoma of the breast and to investigate the correlations among FoxP3+ regulatory ...

journal_title：American journal of translational research

authors： Peng GL,Li L,Guo YW,Yu P,Yin XJ,Wang S,Liu CP

更新日期：2019-08-15 00:00:00

abstract：:We investigated the molecular mechanisms involved in transforming growth factor beta 1 (TGF-β1)-induced myogenic stem cell differentiation to smooth muscle cells. We isolated muscle-derived stem cells (MDSCs) from gastrocnemius muscles following their identification by immunohistochemistry analysis of desmin and flow ...

journal_title：American journal of translational research

authors： Tang X,Su X,Zhong Z,Wen C,Zhang T,Zhu Y

更新日期：2019-08-15 00:00:00

abstract：:Babaodan capsule (BBD), a traditional Chinese (TCM) formula, has been widely used as an alternative remedy for multiple types of malignancies, clinically. However, the underlying mechanisms behind the efficacy of BBD remain poorly understood, particularly in regard to lung cancer. Herein, we demonstrate that BBD induc...

journal_title：American journal of translational research

authors： Wang Q,Liu Z,Du K,Liang M,Zhu X,Yu Z,Chen R,Qin L,Li Y,Zheng Y

更新日期：2019-08-15 00:00:00

abstract：:Digestive system cancers, mainly including gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer, are major public health problems and lead to serious cancer-related deaths worldwide. Clinically, treatment strategies of these cancers include surgery, chemotherapy, and immunotherapy. Althou...

journal_title：American journal of translational research

authors： Song Y,Ye M,Zhou J,Wang Z,Zhu X

更新日期：2019-07-15 00:00:00

abstract：:Although abnormal expression of the long non-coding RNA (lncRNA) MEG3 has been reported in multiple cancer types, the role of MEG3 in the pathobiology of hepatocellular carcinoma (HCC) remains unknown. This study evaluated the expression of lncRNA MEG3 and a microRNA (miRNA-10a-5p) implicated in HCC metastasis in canc...

journal_title：American journal of translational research

authors： Zhang Y,Liu J,Lv Y,Zhang C,Guo S

更新日期：2019-07-15 00:00:00

abstract：:The SDF-1/CXCR4 signaling plays a critical role in the trafficking of mesenchymal stem cells (MSCs) to the sites of tissue damage. Our recent study demonstrated that atorvastatin (ATV) treatment improved the survival of MSCs, and ATV pretreated MSCs (ATV-MSCs) exhibited enhanced engraftment to injured myocardium. In t...

journal_title：American journal of translational research

authors： Tian XQ,Yang YJ,Li Q,Xu J,Huang PS,Xiong YY,Li XD,Jin C,Qi K,Jiang LP,Chen GH,Qian L,Liu J,Geng YJ

更新日期：2019-07-15 00:00:00

abstract：:MicroRNA-302a-5p (miR-302a-5p) has been implicated in several cancers; however, its role in human non-small cell lung carcinoma (NSCLC) remains unknown. In this study, we showed that miR-302a-5p is downregulated in NSCLC tissues and cell lines. Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine assays showed that overe...

journal_title：American journal of translational research

authors： Chen W,Zhuang X,Qi R,Qiao T

更新日期：2019-07-15 00:00:00

abstract：:Resistance to Gemcitabine (GEM) is a crucial problem in treatment of pancreatic cancer. Many studies indicate the direct impact of glycolytic enzyme on chemoresistance. However, it still has not been known whether Enolase 1 (ENO1), a multifunctional glycolytic enzyme, is a potential target to overcome GEM resistance i...

journal_title：American journal of translational research

authors： Wang L,Bi R,Yin H,Liu H,Li L

更新日期：2019-07-15 00:00:00

abstract：:Chronic myelomonocytic leukemia (CMML) can be complicated by autoimmune features associated with rheumatologic disorders, which have been commonly reported by more researches currently. The intrinsic correlation between CMML and autoimmune diseases can create significant pitfalls in differential diagnosis. CMML occasi...

journal_title：American journal of translational research

authors： Bai Z,Chen Y,Chen X,Dong L

更新日期：2019-07-15 00:00:00

abstract：:Human noroviruses (HuNoVs) are a major cause of epidemic and sporadic cases of acute gastroenteritis worldwide. Recently, human intestinal enteroids (HIEs) have been shown to support the replication of HuNoVs, and be an excellent model to study HuNoV-host interactions. We implemented the HIE system in our laboratory a...

journal_title：American journal of translational research

authors： Lin L,Han J,Yan T,Li L,Li J,Ao Y,Duan Z,Hou Y

更新日期：2019-06-15 00:00:00

abstract：:Diabetic cardiomyopathy (DCM) is a condition associated with significant structural changes including cardiac tissue necrosis, localized fibrosis, and hypertrophy of cardiomyocytes. This study sought to assess whether and how CDK4/6 inhibitor, Palbociclib, can attenuate DCM using a streptozotocin (STZ)-induced DCM mod...

journal_title：American journal of translational research

authors： Wang Z,Li J,Wang Y,Liu Q

更新日期：2019-06-15 00:00:00

abstract：BACKGROUND:Atherosclerosis remains a leading cause of cardiology disease worldwide, which vascular smooth muscle cells (VSMCs) proliferation and apoptosis are involved. Increasing evidences have revealed that long non-coding RNAs (lncRNAs) considered to be critical regulatory factors of VSMCs function. However, the mol...

journal_title：American journal of translational research

authors： Wang M,Li C,Zhang Y,Zhou X,Liu Y,Lu C

更新日期：2019-06-15 00:00:00

abstract：:B-cell lymphoma/leukaemia 11A (BCL11A) is a modulator of foetal-to-adult globin switching and is involved in brain development and normal lymphopoiesis. The three-dimensional structure of BCL11A and its structural domains had not yet been completely determined; hence, this study aimed to elucidate the structural domai...

journal_title：American journal of translational research

authors： Abdulazeez S

更新日期：2019-06-15 00:00:00

abstract：BACKGROUND:Accumulating studies have demonstrated that some long non-coding RNAs (lncRNAs) play critical roles in the pathogenesis of atherosclerosis. We aimed to identify circulation lncRNAs that are potential biomarkers to evaluate coronary atherosclerotic plaque stability. METHODS AND RESULTS:The transcriptomes of ...

journal_title：American journal of translational research

authors： Pan Z,Fan Z,Ma J,Liu H,Shen L,He B,Zhang M

更新日期：2019-06-15 00:00:00

abstract：:Ankylosing spondylitis (AS) is a type of rheumatic inflammatory disease. miRNAs participate in the process of regulating inflammatory response and bone differentiation. Herein, we aimed to test the effect of miR-495 on AS. The serum and tissues were obtained from traumatic fracture (health) and AS patients. The human ...

journal_title：American journal of translational research

authors： Du W,Yin L,Tong P,Chen J,Zhong Y,Huang J,Duan S

更新日期：2019-05-15 00:00:00

abstract：:Wound repair is an intractable problem in clinic, with limited treatment options. Previous studies have demonstrated the therapeutic potential of Nogo-B in tissue repairs. However, the therapeutic effect of Nogo-B in HUVEC is still unknown. In this study, we examined the benefit of genetically modified Human Umbilical...

journal_title：American journal of translational research

authors： Wang X,Zheng Y,Wu H,Tian S,Wu M,Luo P,Zhang F,Fang H,Li H,Xia Z

更新日期：2019-05-15 00:00:00

abstract：:Recent studies have shown abnormal expression levels of cyclooxygenase-2 (COX-2) and miR-21b-3p in cerebral ischemia-reperfusion (I/R) rat models. Decreased COX-2 expression could reduce brain injury and thus could be a target of miR-21b-3p according to the miRNA databases (miRDB) analysis. However, its functions and ...

journal_title：American journal of translational research

authors： Wu X,Peng K,Huang H,Li Z,Xiang W,Deng W,Liu L,Li W,Zhang T

更新日期：2019-05-15 00:00:00

abstract：:An ideal implantation of artificial cervical disc replacement (ACDR) prosthesis should preserve the cervical biomechanics and maintain normal cervical biomechanics. In this study, we designed a novel prosthesis based on the physiological curvature of the cervical endplate, and conducted an in vitro test with cadaveric...

journal_title：American journal of translational research

authors： Zhao X,Yuan W

更新日期：2019-05-15 00:00:00

abstract：:Breast cancer is one of the most common cancers among women. Long non-coding RNAs (lncRNAs) are involved in the initiation and development of breast cancer and lncRNA H19 is a potential oncogenic factor; however, the underlying mechanisms remain unknown. In the present study, the regulatory functions of H19 in breast ...

journal_title：American journal of translational research

authors： Si H,Chen P,Li H,Wang X

更新日期：2019-05-15 00:00:00

abstract：:We tested the hypothesis that hyperbaric oxygen (HBO) (100% oxygen/2.4 atmospheres) facilitated the effect of autologous endothelial progenitor cell (EPC) therapy on restoring the blood flow in rat critical-limb ischemia (CLI). Adult-male-SD rats (n = 8/each group) were categorized into group 1 [sham control (SC)], gr...

journal_title：American journal of translational research

authors： Hsu SL,Yin TC,Shao PL,Chen KH,Wu RW,Chen CC,Lin PY,Chung SY,Sheu JJ,Sung PH,Chen CY,Wang CJ,Yip HK,Lee MS

更新日期：2019-04-15 00:00:00

abstract：:Rubus alceaefolius Poir. has been used for the treatment of nasopharyngeal carcinoma (NPC) in China for many years. Euscaphic acid is an active component of Rubus alceaefolius Poir. However, the mechanism of action of euscaphic acid in NPC remains unclear. In this study, Euscaphic acid inhibited the proliferation of N...

journal_title：American journal of translational research

authors： Dai W,Dong P,Liu J,Gao Y,Hu Y,Lin H,Song Y,Mei Q

更新日期：2019-04-15 00:00:00

abstract：:Background/Introduction: Aberrant expression of Toll like receptors (TLR) plays a vital role in pathogenesis of rheumatoid arthritis (RA). Micro RNAs (miRs) could play important role in the related signaling pathways. The present study was undertaken to establish the link between miR-147 and TLR-7 in rat macrophages (...

journal_title：American journal of translational research

authors： Zhao W,Li D,Su Y,Zhao H,Pang W,Sun Y,Wu S

更新日期：2019-04-15 00:00:00

abstract：:Angiotensin II type I receptor agonistic autoantibodies (AT1-AA) in the plasma of preeclampsia patients can induce apoptosis of cardiomyocytes, and microRNA-21 (miR-21) can exert a protective effect on cardiomyocytes. But whether the pro-apoptotic effect of AT1-AA is associated with miR-21 is unclear. The objective of...

journal_title：American journal of translational research

authors： Wang J,Yue J,Xia Q,Jiao X,Zhi J

更新日期：2019-04-15 00:00:00

abstract：:MicroRNAs (miRNAs) are often abnormally expressed in human cancers to act as either oncogenes or tumor suppressor genes. MiRNA-501 (miR-501) has been found to be abnormally expressed in certain types of cancer, but its expression and biological role in hemangioma remain to be fully elucidated. In this study, the expre...

journal_title：American journal of translational research

authors： Zeng Z,Liu S,Cai J,Li Z,Wu H,Chen H,Huang Y

更新日期：2019-04-15 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is a severe infectious disease with high mortality. However, the clinical diagnosis of IPA remains difficult since the microbiological evidence is hard to acquire. The main issue of the current microbiological methods is that they are time-consuming and offer a low yield. Current...

journal_title：American journal of translational research

authors： He BC,Liu LL,Chen BL,Zhang F,Su X

更新日期：2019-04-15 00:00:00

abstract：:Prostate cancer (PCa) is a leading cause of cancer-related deaths among men. The anthracycline doxorubicin (DOX) is used for the treatment of this disease, but its considerable side effects and non-selectivity are major drawbacks. Simvastatin (Sim), a lipid-lowering agent, holds great promise as a cancer therapeutic, ...

journal_title：American journal of translational research

authors： Li N,Xie X,Hu Y,He H,Fu X,Fang T,Li C

更新日期：2019-03-15 00:00:00

abstract：:A random skin flap is commonly applied in plastic and reconstructive surgery. The distal part of the random skin flap often risks necrosis because the blood flow may be compromised. Prevascularization is a widely used technology to intensify the vascularization function of biomaterials. In fact, human mesenchymal stem...

journal_title：American journal of translational research

authors： Zhou F,Zhang L,Chen L,Xu Y,Chen Y,Li Z,Liu X,Wu J,Qi S

更新日期：2019-03-15 00:00:00

abstract：:Nonalcoholic steatohepatitis represents a significant and rapidly growing unmet medical need. The development of novel therapies has been hindered in part, by the limitations of existing preclinical models. There is a strong need for physiologically relevant in vivo and in vitro liver fibrosis models that are characte...

journal_title：American journal of translational research

authors： Mukherjee S,Zhelnin L,Sanfiz A,Pan J,Li Z,Yarde M,McCarty J,Jarai G

更新日期：2019-03-15 00:00:00

abstract：:Circular RNA hsa_circ_0002024 has been reported to be underexpressed in bladder cancer (BC). However, the biological role of hsa_circ_0002024 in BC and its underlying molecular mechanisms remain unclear. In this study, the expression levels of hsa_circ_0002024 and miR-197-3p were examined by quantitative real-time pol...

journal_title：American journal of translational research

authors： Jiang Y,Wei T,Li W,Zhang R,Chen M

更新日期：2019-03-15 00:00:00

abstract：:Intraoperative auto-transfusion with the use of cell saver systems is routinely used to reduce the rate of packed red blood transfusion in major surgery. Nevertheless some concerns have been raised on possible risks of coagulation disorders. The aim of the study was to analyze the blood processed by the cell saver, re...

journal_title：American journal of translational research

authors： Santise G,Maselli D,Malanga D,Di Vito A,Mandarino N,Boccadamo G,Zeppa P,Amorosi A,Viglietto G,Rizzuto A,Mignogna C

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Recurrent hepatocellular carcinoma (rHCC) patients with microvascular invasive (MVI) positive at first resection usually had poorly differentiated tumors and worse survivals. The optimal treatment for this population remains to be elucidated. METHODS:We retrospectively analyzed 319 rHCC patients with MVI-po...

journal_title：American journal of translational research

authors： Xiao H,Chen ZB,Jin HL,Li B,Xu LX,Guo Y,Chen SL,Li HP,Peng ZW,Shen JX

更新日期：2019-03-15 00:00:00